Intestinal Regeneration: YAP—Tumor Suppressor and Oncoprotein?
نویسندگان
چکیده
The Hippo signaling pathway exerts a growth-suppressive effect by inhibitory phosphorylation of the oncogenic transcription co-activator Yki/YAP. A recent study paradoxically reports that genetic removal of YAP enhances intestinal stem cell expansion and regeneration.
منابع مشابه
The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program.
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ورودعنوان ژورنال:
- Current Biology
دوره 23 شماره
صفحات -
تاریخ انتشار 2013